Table 1.

Differential expression of miRNAs between thyroid cancer tissues compared with para-cancer tissues

	MicroRNA	Fold change	P-value
Upregulated	hsa-miR-146a	9.87	8.86e-4
	hsa-miR-146b	11.70	3.12e-5
	hsa-miR-15a	9.11	0.002
	hsa-miR-155	6.46	0.015
	hsa-miR-181a	9.16	1.58e-4
	hsa-miR-181b	7.90	7.77e-4
	hsa-miR-181d	5.22	0.006
	hsa-miR-19a-3p	5.85	0.043
	hsa-miR-221	8.16	3.11e-6
	hsa-miR-222	8.33	1.49e-5
	hsa-miR-34a	10.93	2.15e-8
	hsa-miR-375	5.52	6.90e-5
	hsa-miR-425	6.22	1.48e-4
	hsa-miR-454-3p	3.76	0.021
	hsa-miR-96	5.45	0.008
Downregulated	Hsa-miR-1	3.08	0.006
	Hsa-miR-101	3.93	0.003
	Hsa-miR-10b-3p	4.43	8.30e-4
	Hsa-miR-193b-5p	3.73	2.84e-4
	Hsa-miR-30c-1-3p	3.04	0.007
	Hsa-miR-345-5p	3.85	0.001
	Hsa-miR-374a	4.76	3.24e-4
	Hsa-miR-363-3p	3.16	0.001
	Hsa-miR-370	3.04	0.004
	Hsa-miR-486-5p	3.57	7.90e-4
	Hsa-miR-513a-5p	2.59	0.010
	Hsa-miR-7	5.64	0.002
	Hsa-miR-718	3.22	0.020

Compared with para-cancer tissues, in thyroid cancer tissues, a total of 158 miRNAs whose expression differences with a P-value of less than 0.05. Among them, almost 83 miRNAs expression up-regulated and 75 miRNAs down-regulated.