Table 2.

Mean pharmacokinetic parameters of tolbutamide in rat plasma (X̅±S, n = 6-8)

Parameter	Control	Model	ZTO, 100 mg/kg	ZTO, 200 mg/kg	ZTO, 400 mg/kg
t1/2z (h)	3.27±0.58	3.68±2.13	3.45±0.36	2.73±0.57	12.57±14.54
Cmax (ng/ml)	239.37±21.16	140.70±33.17**	224.77±87.85	80.55±52.02**	89.11±8.47**
AUC(0~∞) (ng/h/ml)	1453.20±415.03	630.45±287.46*	1388.32±626.24	484.29±221.19*	289.63±204.17**
Vz/F (l/kg)	2.11±0.79	124.35±24.82**	2.62±1.44##	5.62±2.42*,##	1432.02±1693.83
CLz/F (l/h/kg)	0.45±0.17	27.95±13.10**	0.51±0.25##	1.49±0.83#	68.20±35.41

^* P < 0.05 vs. control group;

^** P < 0.01 vs. control group;

^# P < 0.05 vs model group;

^## P < 0.01 vs model group.