Table 4.
Mean pharmacokinetic parameters of bupropion in rat plasma (X̅±S, n = 6-8)
| Parameter | Control | Model | ZTO, 100 mg/kg | ZTO, 200 mg/kg | ZTO, 400 mg/kg |
|---|---|---|---|---|---|
| t1/2z (h) | 3.36±1.24 | 3.34±2.19 | 2.52±1.08 | 6.50±5.29 | 4.97±3.94 |
| Cmax (ng/ml) | 275.57±40.07 | 325.60±47.43 | 232.83±43.21# | 365.52±176.83 | 378.56±71.38 |
| AUC(0~∞) (ng/h/ml) | 434.34±57.83 | 528.15±159.15 | 358.47±67.89 | 563.44±193.38 | 447.89±116.70 |
| Vz/F (l/kg) | 163.77±49.95 | 163.72±156.44 | 160.28±74.74 | 232.71±167.28 | 242.30±184.60 |
| CLz/F (l/h/kg) | 35.04±5.04 | 30.34±9.81 | 43.04±8.46 | 29.37±12.10 | 35.14±9.61 |
#
P < 0.05 vs model group.