Table 6.
Mean pharmacokinetic parameters of midazolam in rat plasma (X̅±S, n = 6-8)
| Parameter | Control | Model | ZTO, 100 mg/kg | ZTO, 200 mg/kg | ZTO, 400 mg/kg |
|---|---|---|---|---|---|
| t1/2z (h) | 2.11±1.04 | 3.89±3.91 | 4.69±3.82 | 5.48±3.80 | 4.01±3.82 |
| Cmax (ng/ml) | 414.03±168.77 | 364.54±87.00 | 502.45±276.17 | 381.80±200.32 | 244.30±9.57 |
| AUC(0~∞) (ng/h/ml) | 458.70±126.48 | 414.45±57.03 | 688.32±314.92 | 359.58±145.42 | 323.02±99.81 |
| Vz/F (l/kg) | 104.32±47.81 | 189.04±172.48 | 113.61±80.28 | 202.57±113.19 | 228.00±274.74 |
| CLz/F (l/h/kg) | 34.90±10.78 | 36.67±5.19 | 17.21±7.88*,# | 32.01±15.79 | 33.16±10.85 |
*
P < 0.05 vs. control group;
#
P < 0.05 vs model group.