Table 3.
The polymorphisms of the TLR7 gene and the risk of BCa
| Gene name | Polymorphism | Patients (n = 317) | Controls (n = 317) | OR (95%) | P valuea | |||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| n | % | n | % | |||||
| TLR7 | rs10127190 | TT (584) | 316 | 100.00 | 268 | 100.00 | 1 ref | - |
| TA (0) | 0 | 0.00 | 0 | 0.00 | - | - | ||
| AA (0) | 0 | 0.00 | 0 | 0.00 | - | - | ||
| T (1168) | 632 | 100.00 | 536 | 100.00 | 1 ref | - | ||
| A (0) | 0 | 0.00 | 0 | 0.00 | - | - | ||
| TLR4 | rs11536887 | AA (583) | 317 | 100.00 | 268 | 100.00 | 1 ref | - |
| AG (0) | 0 | 0.00 | 0 | 0.00 | - | - | ||
| GG (0) | 0 | 0.00 | 0 | 0.00 | - | - | ||
| A (1170) | 634 | 100.00 | 536 | 100.00 | 1 ref | - | ||
| G (0) | 0 | 0.00 | 0 | 0.00 | - | - | ||
| MAP3K7 | rs3734657 | CC (537) | 289 | 91.17 | 248 | 92.54 | 1 ref | - |
| CT (47) | 28 | 8.83 | 19 | 7.09 | 0.791(0.431-1.451) | 0.447 | ||
| TT (1) | 0 | 0.00 | 1 | 0.37 | - | - | ||
| C (1121) | 606 | 95.58 | 515 | 96.08 | 1 ref | |||
| T (49) | 28 | 4.42 | 21 | 3.92 | 0.883(0.495-1.573) | 0.671 | ||
| TOLLIP | rs41314515 | CC (584) | 317 | 100.00 | 267 | 99.63 | 1 ref | - |
| TC (1) | 0 | 0.00 | 1 | 0.37 | - | - | ||
| TT (0) | 0 | 0.00 | 0 | 0.00 | - | - | ||
| C (1169) | 634 | 100.00 | 535 | 99.81 | 1 ref | - | ||
| T (1) | 0 | 0.00 | 1 | 0.19 | - | - | ||
| TLR7 | rs5743786 | TT (585) | 317 | 100.00 | 268 | 100.00 | 1 ref | - |
| TC (0) | 0 | 0.00 | 0 | 0.00 | - | - | ||
| CC (0) | 0 | 0.00 | 0 | 0.00 | - | - | ||
| T (1170) | 634 | 100.00 | 536 | 100.00 | 1 ref | - | ||
| C (0) | 0 | 0.00 | 0 | 0.00 | - | - | ||
| TLR7 | rs72552316 | TT (367) | 317 | 100.00 | 50 | 18.66 | 1 ref | - |
| TC (218) | 0 | 0.00 | 218 | 81.34 | - | 0.000 | ||
| CC (0) | 0 | 0.00 | 0 | 0.00 | - | - | ||
| T (952) | 634 | 100.00 | 318 | 59.33 | 1 ref | - | ||
| C (218) | 0 | 0.00 | 218 | 40.67 | - | 0.000 | ||
| TLR6 | rs5743823 | TT (580) | 313 | 99.05 | 267 | 99.63 | 1 ref | |
| TC (4) | 3 | 0.95 | 1 | 0.37 | 0.391(0.040-3.779) | 0.735 | ||
| CC (0) | 0 | 0.00 | 0 | 0.00 | - | - | ||
| C (1164) | 629 | 99.53 | 535 | 99.81 | 1 ref | - | ||
| T (4) | 3 | 0.47 | 1 | 0.19 | 0.392(0.041-3.779) | 0.736 | ||
| TLR4 | rs7869402 | CC (492) | 267 | 84.49 | 225 | 83.96 | 1 ref | - |
| CT (86) | 46 | 14.56 | 40 | 14.93 | 1.032(0.652-1.634) | 0.893 | ||
| TT (6) | 3 | 0.95 | 3 | 1.11 | 1.187(0.237-5.973) | 1.000 | ||
| C (1070) | 580 | 91.77 | 490 | 91.42 | 1 ref | - | ||
| T (98) | 52 | 8.23 | 46 | 8.58 | 1.047(0.692-1.585) | 0.828 | ||
a
The bold numbers mean the P value is < 0.05.