Table 2.
DNMTs expression in RCC and non-tumor tissues
| - | + | ++ | +++ | |||||
|---|---|---|---|---|---|---|---|---|
|
|
||||||||
| n | N (%) | N (%) | N (%) | N (%) | PR, % | P-value | ||
| Clear cell RCC | DNMT1 | |||||||
| Tumor | 60 | 26 (43.3) | 22 (36.7) | 9 (15.0) | 3 (5.0) | 56.7 | 0.019 | |
| non-Tumor | 22 | 16 (72.7) | 3 (13.6) | 2 (9.1) | 1 (4.5) | 27.3 | ||
| DNMT3A | ||||||||
| Tumor | 60 | 22 (36.7) | 20 (33.3) | 13 (21.7) | 5 (8.3) | 63.3 | 0.012 | |
| non-Tumor | 22 | 15 (68.2) | 4 (18.2) | 2 (9.1) | 1 (4.5) | 31.8 | ||
| DNMT3B | ||||||||
| Tumor | 60 | 21 (35.0) | 24 (40.0) | 11 (18.3) | 4 (6.7) | 65.0 | 0.021 | |
| non-Tumor | 22 | 14 (63.6) | 4 (18.2) | 3 (13.6) | 1 (4.5) | 36.4 | ||
| Papillary RCC | DNMT1 | |||||||
| Tumor | 23 | 9 (39.1) | 7 (30.4) | 4 (17.4) | 3 (13.0) | 60.9 | 0.037 | |
| non-Tumor | 18 | 13 (72.2) | 2 (11.1) | 2 (11.1) | 1 (5.6) | 27.8 | ||
| DNMT3A | ||||||||
| Tumor | 23 | 8 (34.8) | 7 (30.4) | 5 (21.7) | 3 (13.0) | 65.2 | 0.019 | |
| non-Tumor | 18 | 13 (72.2) | 3 (16.7) | 2 (11.1) | 0 (0) | 27.8 | ||
| DNMT3B | ||||||||
| Tumor | 23 | 7 (30.4) | 6 (26.1) | 7 (30.4) | 3 (13.0) | 69.6 | 0.003 | |
| non-Tumor | 18 | 14 (77.8) | 3 (16.7) | 1 (5.6) | 0 (0) | 22.2 | ||
| Chomophobe RCC | DNMT1 | |||||||
| Tumor | 14 | 5 (35.7) | 4 (28.6) | 3 (21.4) | 2 (14.3) | 64.3 | 0.041 | |
| non-Tumor | 12 | 10 (83.3) | 1 (8.3) | 1 (8.3) | 0 (0) | 16.7 | ||
| DNMT3A | ||||||||
| Tumor | 14 | 3 (21.4) | 5 (35.7) | 5 (35.7) | 1 (7.1) | 78.6 | 0.022 | |
| non-Tumor | 12 | 8 (66.7) | 2 (16.7) | 1 (8.3) | 1 (8.3) | 33.3 | ||
| DNMT3B | ||||||||
| Tumor | 14 | 3 (21.4) | 6 (42.9) | 3 (21.4) | 2 (14.3) | 78.6 | 0.007 | |
| non-Tumor | 12 | 9 (75.0) | 2 (16.7) | 1 (8.3) | 0 (0) | 25.0 | ||
-, negative; +, weak; ++, moderate; +++, strong staining; PR, positive rate. P-value obtained from Mann-Whitney U test.