Table 4.
Univariate analysis of OS and DFS in patients with RCC (months, mean ± SE)
| Variable | n | Overall survival time | P | Disease-free survival time | P |
|---|---|---|---|---|---|
| Gender | |||||
| Female | 37 | 70.527±5.960 | 0.461 | 67.001±6.542 | 0.811 |
| Male | 60 | 84.772±6.662 | 73.614±6.481 | ||
| Age, years | |||||
| ≤ 55 | 59 | 83.286±6.505 | 0.810 | 75.783±6.511 | 0.709 |
| > 55 | 38 | 72.984±5.755 | 63.374±6.242 | ||
| Histological type | |||||
| Clear cell RCC | 60 | 82.807±6.102 | 0.003 | 74.754±6.219 | 0.026 |
| Papillary RCC | 23 | 58.625±8.444 | 53.610±8.642 | ||
| Chomophobe RCC | 14 | 92.333±7.893 | 82.833±8.982 | ||
| Tumor size (cm) | |||||
| ≤ 4 | 20 | 104.778±7.894 | 0.006 | 91.703±8.859 | 0.021 |
| > 4 | 77 | 67.498±4.322 | 61.987±4.609 | ||
| Tumor pathology stage | |||||
| pT1a | 20 | 96.489±8.586 | 0.000 | 83.074±9.445 | 0.000 |
| pT1b | 25 | 81.086±6.106 | 73.404±6.367 | ||
| pT2a | 17 | 70.261±7.119 | 55.833±6.716 | ||
| pT2b | 11 | 57.659±5.723 | 52.773±5.175 | ||
| pT3a | 16 | 50.500±4.450 | 45.269±4.621 | ||
| pT3b | 2 | 48.000±8.000 | 29.500±0.500 | ||
| pT4 | 6 | 28.500±5.374 | 24.167±7.295 | ||
| Grading | |||||
| G1 | 25 | 83.484±9.098 | 0.024 | 77.446±9.586 | 0.004 |
| G2 | 33 | 80.976±5.847 | 75.247±6.307 | ||
| G3 | 27 | 70.065±7.626 | 61.312±7.579 | ||
| G4 | 12 | 37.661±4.288 | 34.333±4.667 | ||
| Lymph node metastasis | |||||
| pNx | 21 | 72.742±7.890 | 0.000 | 68.129±8.470 | 0.001 |
| pN0 | 62 | 89.848±6.287 | 78.247±6.116 | ||
| pN1/2 | 14 | 47.449±6.461 | 32.643±4.840 | ||
| Vascular invasion | |||||
| No | 91 | 84.366±5.300 | 0.019 | 75.496±5.276 | 0.006 |
| Yes | 6 | 48.625±10.085 | 31.333±4.148 | ||
| Tobacco smoking | |||||
| No | 41 | 91.782±6.990 | 0.082 | 76.597±7.049 | 0.440 |
| yes | 56 | 66.319±4.705 | 63.857±5.480 | ||
| DNMT1 expression | |||||
| Positive | 57 | 61.117±4.768 | 0.004 | 82.823±6.375 | 0.004 |
| Negative | 40 | 92.260±6.174 | 57.251±5.098 | ||
| DNMT3A expression | |||||
| Positive | 64 | 73.291±8.061 | 0.016 | 68.915±8.213 | 0.034 |
| Negative | 33 | 85.291±4.383 | 76.700±5.095 | ||
| DNMT3B expression | |||||
| Positive | 66 | 71.837±7.326 | 0.011 | 63.623±7.690 | 0.003 |
| Negative | 31 | 87.223±4.534 | 80.382±5.157 |