Table 5.
Multivariate analysis of prognostic factors in patients with RCC
| Factor | Overall survival | Disease-free survival | ||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| RRa | 95% CIb | P | RRa | 95% CIb | P | |
| Gender | ||||||
| Male/Female | 1.083 | 0.672-2.817 | 0.853 | 1.214 | 0.713-2.901 | 0.879 |
| Age, years | ||||||
| > 55/≤ 55 | 1.348 | 0.621-2.674 | 0.506 | 1.268 | 0.603-2.593 | 0.623 |
| Tumor size, cm | ||||||
| ≤ 4/> 4 | 7.325 | 4.267-12.383 | 0.031 | 7.865 | 4.612-13.013 | 0.019 |
| Tumor pathology stage | ||||||
| T3-T4/T1-2 | 8.455 | 5.216-13.478 | 0.017 | 8.633 | 5.341-13.652 | 0.014 |
| Grading | ||||||
| 3, 4/1, 2 | 3.231 | 2.216-6.485 | 0.022 | 2.975 | 2.014-3.880 | 0.015 |
| Lymph node metastasis | ||||||
| yes/no | 3.452 | 2.421-6.533 | 0.012 | 3.623 | 2.583-6.632 | 0.008 |
| Vascular invasion | ||||||
| yes/no | 2.286 | 1.783-5.043 | 0.017 | 2.632 | 1.937-5.232 | 0.011 |
| Tobacco smoking | ||||||
| yes/no | 1.476 | 0.843-3.246 | 0.683 | 1.547 | 0.891-3.359 | 0.579 |
| DNMT1 status | ||||||
| positive/negative | 1.598 | 0.926-2.021 | 0.036 | 1.683 | 1.053-2.416 | 0.121 |
| DNMT3A status | ||||||
| positive/negative | 1.662 | 0.985-2.376 | 0.208 | 1.717 | 1.097-2.502 | 0.031 |
| DNMT3B status | ||||||
| positive/negative | 1.713 | 1.035-2.681 | 0.192 | 1.845 | 1.106-2.583 | 0.023 |
a
RR, relative risk;
b
95% CI, 95% confidence interval.