Table 5.
Correlation of expression of metabolism-related proteins between primary and metastatic breast cancer according to metastatic site
| Parameters | Total | Bone metastasis | Brain metastasis | Liver metastasis | Lung metastasis | |||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| n = 49 (%) | P-value | n = 13 (%) | P-value | n = 9 (%) | P-value | n = 4 (%) | P-value | n = 23 (%) | P-value | |
| GNMT | 1.000 | 1.000 | N/A | N/A | 0.500 | |||||
| (+) → (+) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |||||
| (+) → (-) | 1 (2.0) | 1 (7.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |||||
| (-) → (+) | 2 (4.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (8.7) | |||||
| (-) → (-) | 46 (93.9) | 12 (92.3) | 9 (100.0) | 4 (100.0) | 21 (91.3) | |||||
| SARDH | 1.000 | 1.000 | 1.000 | N/A | 1.000 | |||||
| (+) → (+) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |||||
| (+) → (-) | 1 (2.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (4.3) | |||||
| (-) → (+) | 2 (4.1) | 1 (7.7) | 1 (11.1) | 0 (0.0) | 0 (0.0) | |||||
| (-) → (-) | 46 (93.9) | 12 (92.3) | 8 (88.9) | 4 (100.0) | 22 (95.7) | |||||
| PIPOX | 1.000 | 0.375 | 0.500 | N/A | 1.000 | |||||
| (+) → (+) | 4 (8.2) | 1 (7.7) | 0 (0.0) | 0 (0.0) | 3 (13.0) | |||||
| (+) → (-) | 8 (16.3) | 4 (30.8) | 0 (0.0) | 0 (0.0) | 4 (17.4) | |||||
| (-) → (+) | 7 (14.3) | 1 (7.7) | 2 (22.2) | 0 (0.0) | 4 (17.4) | |||||
| (-) → (-) | 30 (61.2) | 7 (53.8) | 7 (77.8) | 4 (100.0) | 12 (52.2) | |||||
(+) and (-) indicate protein expression levels that are positive and negative, respectively. Arrow indicates the change of protein expression from the primary tumor to the metastasis. GNMT, glycine N-methyltransferase; SARDH, sarcosine dehydrogenase; PIPOX, l-pipecolic acid oxidase; N/A, not available.