Figure 6.

Immunodetection of GRHL2 in precursor and cervical cancer tissues. Cervical tissues microarrays (including CIN 1, CIN 3, and CC biopsies) were used to detect GRHL2 by immunohistochemistry. An anti-GRHL2 antibody (HPA004820-Atlas antibodies) was utilized as the primary antibody. Representative images from each histological diagnosis are shown at a magnification of ×40 (A). GRHL2 expression was evaluated by the pathologist and classified according to the degree of positivity: negative, low, medium, or high. Percentages of the tissues found with the different grades of GRHL2 positivity are included (B). The biopsies evaluated for each pathological diagnosis (n) are also included.