Table 1.

Plasma concentrations of MMP-9 in rat model with CPB (μg/L)

	Pre-CPB	T1	T2
Group I	2.31 ± 0.78	3.56 ± 1.12	3.48 ± 1.09
Group II	2.26 ± 0.67	24.06 ± 2.67*	19.35 ± 2.25*
Group III	2.18 ± 0.83	20.72 ± 2.04	12.36 ± 1.89
Group IV	2.56 ± 0.77	19.36 ± 1.78**	9.21 ± 0.97**

Note: Group I (Sham group, underwent cannulation + heparinization only); Group II (CPB group, underwent 60-minutes of normothermic of CPB procedure only); Group III (Low-dose group, underwent 60-minutes of normothermic of CPB which rats administered daily with 30 mg/kg DOX orally one week ahead of CPB); Group IV (High-dose group, underwent 60-minutes of normothermic of CPB which rats administered daily with 60 mg/kg DOX orally one week ahead of CPB). T1 the termination of CPB; T2 6 h after termination of CPB;

^* P < 0.05 vs all groups at the corresponding time points;

^** P < 0.05 vs group II and III at T2 time point.