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. 2014 Dec 18;8(12):e3402. doi: 10.1371/journal.pntd.0003402

Figure 6. Proposed model for the role of NTPD1 in Golgi nucleotide-sugar transport and LPG synthesis.

Figure 6

UDP-galactose and GDP-mannose/GDP-arabinose are transported into the Golgi via transporters LPG5A/LPG5B [37] and LPG2 [65] respectively. Galactose and mannose-phosphate are cleaved for use in phosphoglycan synthesis. Following cleavage, GMP is exchanged for GDP-mannose transport into the lumen. In the case of UDP, hydrolysis to UMP is catalyzed by NTPD1, allowing efficient ongoing transport of UDP-galactose into the Golgi lumen.