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. 2014 Dec 18;9(12):e115252. doi: 10.1371/journal.pone.0115252

Figure 1. Selective inhibition of TCA FIV infectivity by heparin.

Figure 1

(A) Productive infection assay of FIV-PPRcr inhibited by heparin in G355-5 and Gfox cells. (B) Productive infection assay of FIV-34TF10 in G355-5 and FIV-PPR in Gfox cells inhibited by heparin. Virus growth in cells was evaluated as CPM by a reverse transcriptase activity assay over time. Heparin was used at 20 µg/ml. Results are means and standard deviations (SD) for three independent determinations. ***p<0.001; **p<0.01; *p<0.05; as compared to the untreated control group, (C). Effect of heparin on FIV TCA entering G355-5 cells and FS entering Gfox cells. Entry assay were performed in the presence or absence of heparin at indicated concentrations. Values are inhibition percentage calculated as described in “Materials and Methods”. Results are means and standard deviations (SD) for three independent determinations. ***p<0.001; **p<0.01; *p<0.05; as compared to the FIV TCA groups.