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. 2014 Dec 18;9(12):e115252. doi: 10.1371/journal.pone.0115252

Figure 2. Heparin selectively interferes with TCA SU/CXCR4 interactions.

Figure 2

(A) Effect of heparin on TCA or FS SUs-Fc binding to 3201 cells (feline CXCR4) and SupT1 cells (human CXCR4). Heparin was used as 20 µg/ml. Values are inhibition percentage calculated as described in “Materials and Methods”. Results are means and SD for four independent determinations. (B) Heparin interferes with PPRcr or PPR SU-Fc binding to CXCR4 at the indicated concentrations. Values are inhibition percentage. Results are means and SD for three independent determinations. ***p<0.001; **p<0.01; *p<0.05; as compared to the PPR group at the same concentration. (C) Heparin interferes with 34TF10 SU binding to CXCR4. 34 SU-Fc and Fc-34 SU were treated with heparin (20 µg/ml). The top panel and bottom panel represent 3201 cells and SupT1 cells, respectively. Results represent one of three independent experiments.