Table 2. Effects of anti-V3 antibodies on PPRcr or 34TF10 SU-Fc binding to HSPG in G355-5 cells.
Antibodies | Recognition Epitopes | Inhibition | |
PPRcr | 34TF10 | ||
SU1-5 | RPDFESEKVK | – | – |
SU1-7 | conformation dependent | + | + |
SU1-10 | RPDFESEKVK | – | – |
SU1-30 | WRQKNRWEWR | + | + |
SU2-4 | QKNRWEWRPDF | + | + |
SU2-5 | RWEWRPDFES | + | + |
SU2-10 | NRWEWRPDF | + | + |
Percent inhibition was calculated as previously described and are expressed as: “+” = 15–30%; and “–” = 0–15%. All antibodies (initialed with SU) were used at 50 µg/ml as final concentration. Bold and underline amino acid residue is critical for recognition.