. 2014 Dec 18;9(12):e115428. doi: 10.1371/journal.pone.0115428

Table 1. Affinities for inhibiting different targets and phospholipolytic activities of PLA₂s.

PLA₂	Inhibition (IC₅₀, µM) of α-[¹²⁵I]Bgt Binding to…				Current Blocking and Phospholipolytic Activities
	T. californica nAChR	Human α7 nAChR	L. stagnalis AChBP	A. californica AChBP	Inhibition (IC₅₀, µM) of ACh (Cyt)-induced current in L. stagnalis neurons	Phospholipolytic activity, mmol/min/µmol
CM-II	1.2±0.1	3.2±0.3	1.00±0.03	>100	0.37±0.07^*	2.3 [5]
Vurtoxin	0.26±0.02	14±5	>30	>30	10.5±2.6^*	0.7
Vur-PL2	>100	29±2	>30	nd^**	>30	25.1 [19]
Bitanarin	4.3±0.2 [7]	20±1.5 [7]	10.6±0.6 [7]	>50 [7]	4.8±1.3	1.95 [7]

* The data obtained for antagonizing action on currents induced by ACh in nAChR-Ls-1 neurons and by Cyt were combined

** Not determined

Table 1. Affinities for inhibiting different targets and phospholipolytic activities of PLA2s.