Table 2.
Comparison of patients and AVM characteristics in cohorts at 4 institutions.
| UCSF Retrospective n=300 |
UCSF Prospective n=117 |
BNI n=266 |
MGH n=153 |
MU n=173 |
p-value | |
|---|---|---|---|---|---|---|
| Age at resection (y) | <0.001 | |||||
| <20 | 47 (16%) | 33 (28%) | 61 (23%) | 10 (7%) | 29 (17%) | |
| 20–40 | 113 (38%) | 29 (25%) | 91 (34%) | 44 (29%) | 74 (43%) | |
| >40 | 140 (47%) | 55 (47%) | 114 (43%) | 99 (65%) | 70 (40%) | |
| AVM Size (cm) | <0.001 | |||||
| <3 | 194 (65%) | 75 (64%) | 154 (58%) | 110 (72%) | 63 (36%) | |
| 3–6 | 101 (34%) | 40 (34%) | 105 (39%) | 42 (27%) | 102 (59%) | |
| >6 | 5 (2%) | 2 (2%) | 7 (3%) | 1 (1%) | 8 (4%) | |
| Deep venous drainage | 130 (43%) | 48 (41%) | 107 (40%) | 40 (26%) | 62 (36%) | 0.007 |
| Eloquence | 160 (53%) | 70 (60%) | 118 (44%) | 43 (28%) | 73 (42%) | <0.001 |
| Non-hemorrhagic presentation | 143 (48%) | 48 (41%) | 138 (52%) | 81 (53%) | 112 (65%) | 0.001 |
| Diffuse nidus | 37 (12%) | 15 (13%) | 59 (22%) | 42 (27%) | 69 (40%) | <0.001 |
| Spetzler-Martin Grade | ||||||
| 1 | 55 (18%) | 25 (21%) | 64 (24%) | 63 (41%) | 28 (16%) | |
| 2 | 122 (41%) | 36 (31%) | 92 (35%) | 56 (37%) | 69 (40%) | |
| 3 | 92 (31%) | 43 (37%) | 79 (30%) | 31 (20%) | 48 (28%) | |
| 4 | 29 (10%) | 12 (10%) | 30 (11%) | 3 (2%) | 24 (14%) | |
| 5 | 2 (1%) | 1 (1%) | 1 (<1%) | 0 (0%) | 6 (2%) | |
| Supplemented Spetzler-Martin Grade | 0.001 | |||||
| 2 | 8 (3%) | 5 (4%) | 8 (3%) | 2 (1%) | 1 (1%) | |
| 3 | 20 (7%) | 8 (7%) | 23 (9%) | 5 (3%) | 4 (2%) | |
| 4 | 55 (18%) | 27 (23%) | 54 (20%) | 35 (23%) | 32 (19%) | |
| 5 | 92 (31%) | 31 (27%) | 66 (25%) | 63 (41%) | 39 (23%) | |
| 6 | 72 (24%) | 31 (27%) | 65 (24%) | 19 (12%) | 45 (26%) | |
| 7 | 41 (14%) | 9 (8%) | 32 (12%) | 23 (15%) | 33 (19%) | |
| 8 | 9 (3%) | 3 (3%) | 15 (6%) | 5 (3%) | 16 (9%) | |
| 9 | 3 (1%) | 2 (2%) | 3 (1%) | 1 (1%) | 2 (1%) | |
| 10 | 0 (0%) | 1 (1%) | 0 (0%) | 0 (0%) | 1 (1%) | |
| Pre-op mRS | <0.001 | |||||
| 0 | 85 (28%) | 26 (22%) | 41 (15%) | 22 (14%) | 94 (54%) | |
| 1 | 65 (22%) | 33 (28%) | 109 (41%) | 53 (35%) | 26 (15%) | |
| 2 | 33 (11%) | 21 (18%) | 60 (23%) | 39 (25%) | 25 (14%) | |
| 3 | 55 (18%) | 16 (14%) | 26 (10%) | 17 (11%) | 13 (8%) | |
| 4 | 33 (11%) | 9 (8%) | 12 (5%) | 13 (9%) | 3 (2%) | |
| 5 | 29 (10%) | 12 (10%) | 18 (7%) | 9 (6%) | 12 (7%) | |
| Post-op mRS | <0.001 | |||||
| 0 | 96 (32%) | 43 (37%) | 91 (34%) | 28 (18%) | 99 (57%) | |
| 1 | 88 (29%) | 34 (29%) | 74 (28%) | 54 (35%) | 27 (16%) | |
| 2 | 52 (17%) | 25 (21%) | 54 (20%) | 45 (29%) | 33 (19%) | |
| 3 | 21 (7%) | 9 (8%) | 22 (8%) | 16 (10%) | 6 (3%) | |
| 4 | 15 (5%) | 5 (4%) | 13 (5%) | 3 (2%) | 0 (0%) | |
| 5 | 1 (<1%) | 0 (0%) | 6 (2%) | 2 (1%) | 1 (1%) | |
| 6 | 27 (9%) | 1 (1%) | 6 (2%) | 5 (3%) | 7 (4%) | |
| Worsening of mRS | 77 (26%) | 25 (21%) | 51 (19%) | 35 (23%) | 34 (20%) | |
| Time from surgery to last mRS (y) | 1.69 ± 1.69 | 0.99 ± 1.05 | 2.12 ± 2.35 | 1.80 ± 2.42 | 2.51 ± 3.17 | 0.008* |
Values are the number observed with the specified value (and percentage) or the mean ± standard deviation.
P-values are derived from a chi-square test or ANOVA.
This p-value is based on comparison of log-transformed values.