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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Genet Epidemiol. 2014 Nov 21;39(1):35–44. doi: 10.1002/gepi.21866

Figure 2.

Figure 2

Simulated cumulative site frequency spectra in three human continental groups under several recently inferred demographic models. Sample size is 103 chromosomes in the top panels and 5 × 103 chromosomes in the lower panels. Note that the model of Tennessen et al. [2012] did not infer demography of the Asian continental group, so we do not plot a curve for this population. However, the Asian continental group is included in the Tennessen et al. [2012] simulations. Each curve was calculated using 103 independent simulations of 5 × 103 base pairs each. The gray dashed curve represents the analytical expectation based on the standard neutral model and is not the result of simulations. (SNM: standard neutral model, AFR: African population, EUR: European population, ASN: Asian population, NS: non-synonymous, SYN: synonymous).