Skip to main content
. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: J Neurosci Res. 2014 Sep 16;93(2):230–243. doi: 10.1002/jnr.23477

Figure 5.

Figure 5

Nicotine-induced activation of c-Fos at three representative sites in the mouse brain. Bars represent the mean (± standard error) number of c-Fos activated cells counted in ventral tegmental area (VTA), nucleus accumbens (Acb) and prefrontal cortex (PFC). c-Fos immunoreactivity was assessed following intraperitoneal administration of normal physiological saline (NS, control), nicotine hydrogen tartrate salt (NIC) or its peripherally-acting analog nicotine pyrrolidine methiodide (NIC-PM). Differences between the NS control and NIC or NIC-PM treatments were significant at †P<0.001 and between NIC and NIC-PM were significant at *P≤0.05, **P<0.001.