A: Relative mRNA expression of CatC in bone-marrow- derived macrophages (BMDM) of donor WT and CatC−/− mice (n=4) in basal conditions and after stimulation with IL-4 and IFNγ in vitro. B: Relative mRNA expression (Q-PCR) of CatK and CatS after M1 and M2 macrophage polarization. Relative mRNA expression of iNOS (C), in BMDM in basal conditions and after stimulation with IL-4 and IFNγ in vitro, YM-1 expression is shown in basal conditions only (D), donor WT and CatC−/− mice (n=4). * p<0.05, **= p<0.01, ***p<0.001