Table 3. Mendelian randomisation analysis of SU versus Tg using uric acid transporter single genetic variants as instrumental variables in the combined ARIC and FHS sample set.
| F-statistics | R2 | Beta* | SE† | P | DHP‡ | |||
|---|---|---|---|---|---|---|---|---|
| All | ||||||||
| rs11942223 (SLC2A9) | 228.71 | 0.0271 | -0.408 | 0.704 | 0.562 | <0.00001 | ||
| rs2231142 (ABCG2) | 61.14 | 0.0074 | 1.211 | 1.401 | 0.387 | 0.286 | ||
| rs2078267 (SLC22A11) | 19.13 | 0.0023 | -5.262 | 3.037 | 0.083 | 0.002 | ||
| rs1183201 (SLC17A1) | 15.11 | 0.0018 | 0.103 | 2.347 | 0.965 | 0.261 | ||
| rs3825018 (SLC22A12) | 11.93 | 0.0015 | -3.156 | 3.535 | 0.372 | 0.072 | ||
| Males | ||||||||
| rs11942223 (SLC2A9) | 75.64 | 0.0197 | -0.924 | 1.775 | 0.599 | 0.022 | ||
| rs2231142 (ABCG2) | 53.48 | 0.014 | 0.027 | 2.098 | 0.990 | 0.157 | ||
| rs2078267 (SLC22A11) | 8.24 | 0.0022 | -7.633 | 5.832 | 0.191 | 0.028 | ||
| rs1183201 (SLC17A1) | 11.64 | 0.0031 | 1.115 | 4.122 | 0.787 | 0.659 | ||
| rs3825018 (SLC22A12) | 5.63 | 0.0015 | -2.426 | 5.446 | 0.656 | 0.299 | ||
| Females | ||||||||
| rs11942223 (SLC2A9) | 316.16 | 0.0665 | -0.200 | 0.591 | 0.735 | <0.00001 | ||
| rs2231142 (ABCG2) | 37.24 | 0.0083 | 2.657 | 1.841 | 0.149 | 0.855 | ||
| rs2078267 (SLC22A11) | 15.64 | 0.0035 | -3.320 | 2.936 | 0.258 | 0.031 | ||
| rs1183201 (SLC17A1) | 17.25 | 0.0039 | -0.428 | 2.412 | 0.859 | 0.239 | ||
| rs3825018 (SLC22A12) | 4.75 | 0.0011 | -2.940 | 3.804 | 0.440 | 0.125 | ||
Adjusted by study data set, sex (in ‘All’), age, BMI and the first two Eigen values of genome-wide principal component analysis
*
Beta represents the change in serum Tg (mmol/L) attributed to a unit change in SU attributed to the instrumental variable in the two-stage least squares analysis.
†
Standard error
‡
Durbin-Hausman P value