Table 4. Mendelian randomisation analysis of serum Tg against serum urate using the triglyceride genetic risk score instrumental variable.

			Ordinary Least Square Regression			Two-stage Least Square
			Beta‡	SE§	P	Beta‡	SE§	P	DH P║
ARIC Europeans	All	Crude*	0.026	0.001	1.44E-100	0.010	0.010	0.304	0.113
		Adjusted†	0.014	0.001	6.13E-42	0.008	0.008	0.336	0.436
	Males	Crude	0.016	0.001	5.61E-29	0.015	0.011	0.165	0.955
		Adjusted	0.012	0.001	1.72E-16	0.020	0.010	0.037	0.356
	Females	Crude	0.026	0.002	3.42E-56	-0.010	0.015	0.520	0.011
		Adjusted	0.017	0.002	5.44E-27	-0.012	0.014	0.387	0.029
FHS Europeans	All	Crude	0.031	0.0016	1.15E-82	0.007	0.011	0.505	0.020
		Adjusted	0.014	0.0012	7.08E-29	0.012	0.007	0.104	0.802
	Males	Crude	0.015	0.0015	8.26E-23	0.020	0.009	0.035	0.607
		Adjusted	0.012	0.0015	6.98E-16	0.022	0.009	0.016	0.279
	Females	Crude	0.032	0.0023	1.80E-39	-0.016	0.016	0.286	0.0005
		Adjusted	0.019	0.0023	3.78E-15	-0.005	0.013	0.709	0.050
Combined	All	Crude	0.029	0.001	1.32E-191	0.005	0.008	0.491	0.001
		Adjusted	0.014	0.001	1.80E-70	0.009	0.006	0.095	0.306
	Males	Crude	0.016	0.001	1.27E-50	0.017	0.007	0.025	0.860
		Adjusted	0.012	0.001	1.52E-30	0.021	0.007	0.002	0.166
	Females	Crude	0.031	0.001	6.13E-112	-0.023	0.013	0.076	<0.00001
		Adjusted	0.018	0.001	6.55E-43	-0.008	0.010	0.403	0.002

The center-side is the standard linear (ordinary least square) regression between the explained variables (SU and serum Tg) and the right-side is the two-stage least squares analysis.

^*Unadjusted

^†Adjusted by study data set (in combined), sex (in ‘All’), age, BMI, first two Eigen values of genome-wide SNP (in ARIC, FHS and combined).

^‡Beta represents the change in SU (mmol/L) attributed to a unit change in Tg in the linear regression (on the center) and the change in SU (mmol/L) caused by a unit change in serum Tg attributed to the instrumental variable in the two-stage least squares analysis (on the right).

^§Standard error

^║Durbin-Hausman P value