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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Stem Cells. 2015 Jan;33(1):278–288. doi: 10.1002/stem.1852

Fig. 1. LT-HSCs express the highest levels of NR4A1.

Fig. 1

Lineage-depleted (Lin−) NR4A1GFP transgenic (Tg) reporter mouse bone marrow (BM) cells were isolated, stained and analyzed by flow cytometry. Non-Tg littermates were used as controls (grey). (A) Relative NR4A1GFP expression levels in hematopoietic subpopulations: Myelo Prog, myeloid-committed progenitors (Lin−Sca-1−c-Kit+); LSKs, Lin−Sca-1+c-Kit+ cells; LT-HSCs, long-term hematopoietic stem cells. (B) Proportional contribution of LT-HSC compartment (CD150+CD48−) to LSKs with increasing NR4A1GFP expression levels. Data are from four independent experiments, each using 1-2 NR4A1GFP Tg mice and 1-2 non-Tg littermate control mice. P-values were calculated using unpaired, one-tailed student’s t-test.