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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Circ Cardiovasc Genet. 2014 Sep 23;7(6):887–894. doi: 10.1161/CIRCGENETICS.114.000738

Table 4.

Analysis of allelic association of SNP rs4400166 with CAD in Chinese Han population

Cohort
(n, case/control)		 Risk
Allele		 Frequency
(case/control)		 Without Adjustment With Adjustment*
P-obs OR (95% CI) P-adj OR (95% CI)
Validation cohort (924/904) A 0.23/0.19 9.30×10−3 1.24(1.05–1.45) 0.03 1.20(1.01–1.43)
Replication cohort (1065/1398) A 0.22/0.19 8.41×10−3 1.21(1.05–1.40) 0.01 1.18(1.02–1.41)
Combined (1989/2302) A 0.22/0.19 1.69 ×10−4 1.23(1.10–1.36) 4.43×10−3 1.18(1.02–1.40)

P-obs: P value observed; P-adj: P value after adjustment for covariates; OR: odds ratio.

*

Adjusted P value by multivariate logistic regression analysis for potential confounders including age, gender, smoking, hypertension, diabetes mellitus and lipid concentrations (total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol).