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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2015 Jan;74(1):75–84. doi: 10.1097/NEN.0000000000000151

Figure 2.

Figure 2

Proportion of cases with Hippocampal sclerosis of aging (HS-Aging) pathology by age group at death and genotype. (A-C) Genotypes are shown for rs1990622 (TMEM106B; panel A); rs704180 (ABCC9; panel B); and rs5848 (GRN; panel C). These analyses factor in the results of all the cases (n = 3498 total), with case/control operationalizations as described in Methods. Note that HS-Aging pathology is most common in the “oldest-old”, and that the previously described risk genotypes (rs1990622 A_A; rs704180 A_A; and rs5848 T_T) have the highest risk for HS-Aging pathology across multiple age groups. For statistical analyses of relevant odds ratios, see Table 2.