Table 2.
NACC data available for use in prior study (n = 186 HS−Aging, 2157 controls) | ||||
Additive MOI |
Dominant MOI |
Recessive MOI |
||
SNP | Risk allele* | Odds ratio (95% CI) |
Odds ratio (95% CI) |
Odds ratio (95% CI) |
ABCC9
(rs704180) |
A | 1.51 (1.22-1.89) |
1.46 (0.99-2.17) |
1.90 (1.40-2.60) |
TMEM106B
(rs 1990622) |
A | 1.16 (0.94-1.44) |
1.18 (0.80-1.75) |
1.24 (0.91-1.70) |
GRN (rs5848) | T | 1.25 (0.99-1.59) |
1.33 (0.97-1.82) |
1.35 (0.80-2.30) |
NACC data unavailable for use in prior study (Replication cohort) (n = 51 HS−Aging, 561 controls) | ||||
Additive MOI |
Dominant MOI |
Recessive MOI |
||
SNP | Risk allele* | Odds ratio (95% CI) |
Odds ratio (95% CI) |
Odds ratio (95% CI) |
ABCC9
(rs704180) |
A | 1.38 (0.93-2.05) |
1.13 (0.59-2.18) |
2.00 (1.10-3.60) |
TMEM106B
(rs 1990622) |
A | 1.86 (1.22-2.86) |
2.70 (1.21-3.84) |
2.14 (1.21-3.84) |
GRN (rs5848) | T | 1.74 (1.12-2.69) |
2.24 (1.16-4.33) |
1.92 (0.80-4.59) |
HS−Aging, hippocampal sclerosis of aging; CI, confidence interval; MOI, mode of inheritance, SNP, single nucleotide polymorphisms.
Data are for the additive, dominant, and recessive models of MOI.
See Materials and Methods for description of rationale for risk allele identification.