Table 2.

Risk Alleles, p Values, and Odds Ratios, with 95% Confidence Intervals for National Alzheimer’s Coordinating Center Datasets

NACC data available for use in prior study (n = 186 HS−Aging, 2157 controls)
		Additive MOI	Dominant MOI	Recessive MOI
SNP	Risk allele*	Odds ratio (95% CI)	Odds ratio (95% CI)	Odds ratio (95% CI)
ABCC9 (rs704180)	A	1.51 (1.22-1.89)	1.46 (0.99-2.17)	1.90 (1.40-2.60)
TMEM106B (rs 1990622)	A	1.16 (0.94-1.44)	1.18 (0.80-1.75)	1.24 (0.91-1.70)
GRN (rs5848)	T	1.25 (0.99-1.59)	1.33 (0.97-1.82)	1.35 (0.80-2.30)
NACC data unavailable for use in prior study (Replication cohort) (n = 51 HS−Aging, 561 controls)
		Additive MOI	Dominant MOI	Recessive MOI
SNP	Risk allele*	Odds ratio (95% CI)	Odds ratio (95% CI)	Odds ratio (95% CI)
ABCC9 (rs704180)	A	1.38 (0.93-2.05)	1.13 (0.59-2.18)	2.00 (1.10-3.60)
TMEM106B (rs 1990622)	A	1.86 (1.22-2.86)	2.70 (1.21-3.84)	2.14 (1.21-3.84)
GRN (rs5848)	T	1.74 (1.12-2.69)	2.24 (1.16-4.33)	1.92 (0.80-4.59)

HS−Aging, hippocampal sclerosis of aging; CI, confidence interval; MOI, mode of inheritance, SNP, single nucleotide polymorphisms.

Data are for the additive, dominant, and recessive models of MOI.

^*See Materials and Methods for description of rationale for risk allele identification.