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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Circ Cardiovasc Genet. 2014 Jul 21;7(5):615–624. doi: 10.1161/CIRCGENETICS.113.000398

Figure 5.

Figure 5

TLR4 regulates platelet aggregation following HS-R. Aggregometry was performed on wild-type (TLR4 +) or mice lacking TLR4 on their platelets (TLR4 −). Results are expressed as the area under the aggregometry curve, measured as arbitrary units/minute (AU*min). A: Ex vivo collagen (5ug/ml) treatment of platelets demonstrates no significant difference in aggregation between groups. N=8 mice/group. p=NS. B: Aggregometry from either control (pre-shock blood draw) vs HS-R (post-shock). Collagen (5ug/ml) was present as the agonist in all samples. N=5 mice/group. C: Representative aggregometry tracings from control and HS-R. Each y axis block represents 10% change and each x axis block is 1 minute.