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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Nat Chem Biol. 2014 Nov 17;11(1):58–63. doi: 10.1038/nchembio.1690

Figure 3. GSK-3 inhibition sensitizes cells to PLK1 inhibitors.

Figure 3

Inhibition of GSK-3 activity via CHIR sensitizes cells to PLK1 inhibition with PLK1 RNAi (a,c) the small molecule GSK461364 (b,d). We measured either fragmented nuclei after 72 hours treatment (a,b) or cleaved caspase-3/7 activity after 48 hours of treatment (c,d). Data points were normalized to the control; each point represents mean values ± s.d. from two biological replicates. Statistical significance was determined using a K-S test (Supplementary Note); * indicates p-values < 0.01. (Scale bars, 25 μm.)