Table 1.

Existing (Method 0) and newly-proposed (Methods 1-4) multi-trial copula modeling and estimation methods.

Name	Copula Type	Association Modeling	Estimation
Method 0	Clayton - Survival	Equal across trials	Simultaneous
Method 1	Clayton - CDF	Equal across trials	Simultaneous
Method 2	Clayton - CDF	Trial-specific	Simultaneous
Method 3	Clayton - CDF	Equal across trials	Two stage
Method 4	Clayton - CDF	Trial-specific	Two stage