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. 2014 Jun 18;19(2):260–270. doi: 10.1002/ejp.544

Figure 4.

Figure 4

Intrathecal injection of the JNK inhibitor SP600125 attenuates carrageenan-induced thermal hypersensitivity. (A) Graphs depicting the effect of SP600125 (3.3 and 33 μg, i.t.), injected i.t. 15 min before carrageenan injection on thermal paw withdrawal latencies over time compared with i.t. vehicle (5% Tween-80, 20% DMSO in saline) injected group. (B) Bar graphs showing the hyperalgesic index calculated for the 0–240 min time period after carrageenan injection. All data are presented as mean ± SEM, *p < 0.05; **p < 0.01; ***p < 0.001, versus vehicle controls.