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. 2014 Jun 18;19(2):260–270. doi: 10.1002/ejp.544

Figure 5.

Figure 5

Intrathecal injection of the JNK inhibitor JIP-1 attenuates carrageenan-induced thermal and mechanical hypersensitivity. Graphs showing effects of JIP-1 (0.3–30 μg) or vehicle (saline)-injected i.t. 15 min before carrageenan injection on (A) thermal withdrawal latencies and (C) mechanical withdrawal thresholds. (B and D) Bar graphs showing the related hyperalgesic indeces for the 0–240 min time period after carrageenan injection. All data are presented as mean ± SEM, *p < 0.05; **p < 0.01; ***p < 0.001, versus vehicle controls.