Figure 1.

Partial Receiver Operating Curves (ROC) showing the percentage of cases of breast cancer expected to occur in groups of the population at highest predicted risk (A, C), and graphs for the percentage of the population crossing breast cancer relative risk (RR) thresholds (compared with the average risk in the population) (B, D). Estimates are for a UK population of women aged 50 years, for eight risk prediction models, including different sets of risk factors and two polygenic risk scores (PRSs): the 76–single nucleotide polymorphism (SNP) PRS based on currently known SNPs explaining 15% of the familial risk (A, B) and an improved PRS explaining 30% of the familial risk (C, D). PRS = polygenic risk score; Qx = questionnaire; SNP = single nucleotide polymorphism.