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Effects of BAs on the mRNA levels of BA sensors FXR and TGR5. Human primary hepatocyte cultures were treated with individual BAs at concentrations of 10, 30, and 100μM for 48 h, and the expression of FXR and TGR5 was determined by real-time RT-PCR analysis. Data are mean + SEM (n = 6). *Significantly different from DMSO-treated controls, p < 0.05.
