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Colony counts of Pseudomonas aeruginosa ATCC 27853 in the lungs of mice. Cohorts were euthanized at baseline (2 hours after challenge), at hour 26, and at hour 50. The difference between the data for 26 h and 50 h reflects the influence of granulocytes acting alone on the bacterial burden at hour 26. The untreated controls and the group treated with the lowest dose of plazomicin (5.5 mg/kg/d) were humanely euthanized at hour 26.
