Table 1.
Pharmacokinetic Parameter Values
| Measure | Vc, L | CL/F, L/H | K23, H−1 | K32, H−1 | K24, H−1 | K42, H−1 | VELF, L | Ka, × 1/H |
|---|---|---|---|---|---|---|---|---|
| Mean ± SD | 0.0189 ± 0.0164 | 0.0301 ± 0.0219 | 11.09 ± 2.221 | 10.69 ± 3.555 | 6.120 ± 2.297 | 13.74 ± 2.147 | 0.0045 ± 0.0025 | 28.04 ± 1.775 |
| Median | 0.0071 | 0.0109 | 9.060 | 13.92 | 4.292 | 15.45 | 0.0023 | 28.86 |
Abbreviations: CL/F, apparent plasma clearance rate; H, Hill's constant; Ka, first order absorption rate constant; K23, K24, K32, K42, first order intercompartmental transfer rate constants; Vc/F, apparent volume of the central compartment; VELF, volume of the epithelial lining fluid compartment.