Table 2.

Parameter Values for the Pharmacodynamic Model

Measure	Kgmax, H−1	Kkillmax, H−1	C50-Plazo-Kill, mg/L	H	Popmax, CFU	IC5, CFU	KkillWBC, H−1	WBCKill50, CFU/g
Mean ± SD	0.523 ± 1.370	2.578 ± 2.305	15.32 ± 5.408	16.77 ± 2.277	9.08 × 109 ± 2.23 × 109	8.50 × 107 ± 2.87 × 107	0.730 ± 1.007	2.45 × 106 ± 6.84 × 105
Median	0.057	1.256	16.94	18.49	9.86 × 109	5.60 × 107	0.354	2.68 × 106

In the system output, CFU/g values are log₁₀ transformed.

Abbreviations: C_{50-Plazo-Kill}, plazomicin concentration at which the plazomicin-attributable kill is half maximal; H, Hill's constant; IC₅, initial bacterial burden at therapy initiation; K_gmax, first order growth rate constant; K_killmax, maximal kill rate constant for plazomicin therapy; K_killWBC, maximal kill rate attributable to granulocytes; Pop_max, maximal size of the bacterial population; WBC_Kill50, bacterial burden at which granulocyte-mediated kill is half saturable.