Figure 7.

Orthoginal confirmation of cognition-related suppression of transthyretin. Transthyretin (Ttr) expression (A) was confirmed across all three groups and brain regions. In both the CA3 and DG, a significantly lower level of Ttr expression was observed, with a similar trend in CA1 (analysis of variance, SNK post hoc **p < .01, *p < .05, n = 5–7 Aged, n = 8–9 Aged Intact, n = 11–12 Aged Impaired). To treat the behavioral performance as a continuum rather than as two populations, Ttr expression was correlated to behavioral performance in Aged animals. In both the CA3 (B) and DG (C), Ttr expression negatively correlated to mean proximity to platform distance in the probe trial, that is, lower Ttr expression was associated with worse behavioral performance. Pearson correlation, *p < .05, **p < .01, n = 21 CA3, n = 19 DG.