TABLE 2. Effect of In Utero TCDD Exposure on Abundance and Localization of RNA from Wnt Signaling Modulators in Mouse UGS at E16.5^a.

^aAt least three litter-independent UGSs per treatment group were used to determine RNA abundance and localization for each gene. Corn oil (vehicle) or TCDD (5 μg/kg, po) was administered to pregnant dams on E15.5. A horizontal arrow denotes that RNA was detected in the indicated tissue compartment and that there was no detectable difference in RNA abundance or localization between vehicle- and TCDD-exposed UGSs at E16.5. Downward-pointing arrows indicate that TCDD decreased transcript abundance compared with vehicle-exposed control UGSs. No arrow indicates that transcript was not detected.

^bBasal epithelium = epithelial cells bordering mesenchyme.

^cIntermediate epithelium = epithelial cells that do not border mesenchyme or lumen.

^dVentral lamina propria = mesenchyme immediately adjacent to the epithelium in the ventral UGS.

^eBecause the reported functions of Wnt signaling modulators can vary from system to system, genes were sorted by the subcellular localization of their proteins rather than sorted by function.