FIGURE 6.

Administration of ManNAc in the drinking water of treated mice fails to abrogate the effects of 3F-NeuAc. A, SNA staining on peripheral blood B cells 7 days after mice received a single 300 mg·kg⁻¹ intravenous injection of 3F-NeuAc, with or without co-administration of ManNAc. The data are representative of four replicates. B, average body weight of mice (n = 16) treated with a single 300 mg·kg⁻¹ intravenous injection of 3F-NeuAc and ManNAc in the drinking water shows the same phases of weight gain and loss as seen in mice that did not receive ManNAc. The data represent the means ± S.E. C, immunoblots of whole kidney lysates for podocalyxin, 11 and 21 days after mice received a single 300 mg·kg⁻¹ intravenous injection of 3F-NeuAc, with or without co-administration of ManNAc. Max, maximum; WB, Western blotting.