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. 2014 Oct 24;289(51):35351–35362. doi: 10.1074/jbc.M114.593376

FIGURE 1.

FIGURE 1.

Background. a, protein sequence homology of all retaining β-glucosidases expressed in man, categorized in glycosylhydrolase families GH1, -30, and -116. b, double displacement mechanism of retaining β-glucosidases, with distinct acid/base (A/B, top) and nucleophile (N, bottom). c, structure formulas of cyclophellitol-based ABP 1 (MDW933 (29)) and aziridine containing ABP 2 (MDW1044 (30)) and their nucleophile binding mechanisms (d and e, respectively). Azide-mediated rescue of hydrolysis in case of absent acid/base (f) or nucleophile (g).