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HDX of β-strand D1. A, HDX plot of peptide 201–208 from strand D1. B, structural representation of the D1 strand. The calcium ion is depicted as a yellow sphere. Individual sites that are likely to undergo reduced HDX upon TF binding based on ETD measurements on peptide 201–208 are localized to residues Asn-203-Ile-205 (PDB ID: 1DAN). H-bonds involving amide hydrogens from residues Asn-203 and Ile-205 that are likely to be destabilized or absent in unbound FVIIa are shown in lime.
