Hes3 regulates responses to challenge by glucose/KCl in MIN6 cell cultures.
A–C, insulin content, released insulin, and stimulation index measurements by ELISA (stimulation index is expressed as % of control siRNA) following transfection with either a control siRNA or Hes3 siRNA show that opposing Hes3 expression reduces the responsiveness to stimulation in MIN6 cells cultured in DC (n = 3; errors bars represent S.E. R, resting state; S, stimulated state).