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Model of X11α/kalirin-7 interaction. Kalirin-7 enhances Rac1 activation in dendritic spines, leading to actin cytoskeletal rearrangements, spine growth, and recruitment of AMPA receptors. X11α binding to kalirin-7 inhibits its GEF activity, recruits it to Golgi outposts in the dendrite, and induces spine shrinkage.
