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. 2014 Nov 3;289(51):35620–35632. doi: 10.1074/jbc.M114.614917

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 13. — Proposed Pyl enzymatic reaction to form UDP-Yelosamine. Conversion of ATP, 2OG, and UDP-4-amino-FucNAc to UDP-Yelosamine by Pyl. The carboxylate group of 2OG attacks (step 1) the γ-phosphate of ATP, forming an activated intermediate (2OG-phosphate) and ADP. The 4″-amino group of UDP-amino-FucNAc attacks the “activated” C-5 carbonyl moiety attached to a 2OG-phosphate intermediate (step 4). This yields presumably an unstable tetrahedral intermediate that is collapsed, releasing UDP-Yelosamine, a phosphate, and ADP.