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. 2014 Nov 1;14:170. doi: 10.1186/1471-2466-14-170

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© Myllärniemi et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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INHBB and follistatin mRNA expression is increased in IPF lung. A. The mRNA expression levels of TGF-ß/BMP pathway genes in human idiopathic pulmonary fibrosis (IPF) lung (N = 4) and control lung (N = 4) were measured using a PCR array. In the scatter plot, IPF group is plotted against the control group. At least threefold differences in mRNA expression levels are indicated with green (upregulation) and red (downregulation) color. INHBB and follistatin mRNA expression was increased 3.8-fold and 3.6-fold, respectively. Col, collagen; LTBP1, latent TGF-ß binding protein; IGF, insulin-like growth factor; IGFBP, IGF binding protein; BMP, bone morphogenetic protein. B. INHBB and FST mRNA expression levels were confirmed by quantitative RT-PCR.