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. 2014 Nov 1;14:170. doi: 10.1186/1471-2466-14-170

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© Myllärniemi et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of activin inhibition to mouse body composition after particulate exposure. A. Effect of activin inhibition using sActRIIB-Fc on body mass of mice exposed oropharyngeally to either asbestos or silica dust. E1 and E2 show time points of dust exposure. B. Effect of activin inhibition on skeletal muscle mass. In asbestos-exposed animals, 5 animals with equal starting mass were chosen for measurement. In silica-exposed animals N = 9 and in controls N = 6. C. Epididymal and retroperitoneal fat masses of mice treated with sActRIIB-Fc and exposed to either asbestos (Asb, A; N = 5/group) or silica (B; N = 9 in the exposed animal groups and N = 5 in the control (Ctrl) group).