Table 2.
Association analysis of SNPs in TF and TFPI between the sepsis and severe sepsis groups
| Gene | Sepsis | Severe sepsis | Allelic comparison | Genotypic comparison | ||||
|---|---|---|---|---|---|---|---|---|
| SNP | patients | patients | P 1 adj | OR 1 adj (95% CI) | P 2 adj | OR 2 adj (95% CI) | P 1 adj | P 2 adj |
| TF | ||||||||
| rs1324214 | 0.13 | 0.86 (0.71 to 1.05) | 0.22 | 0.89 (0.83 to 1.04) | 0.09 | 0.14 | ||
| CC | 270 (47.8%) | 253 (54.2%) | ||||||
| CT | 270 (47.8%) | 191 (40.9%) | ||||||
| TT | 25 (4.4%) | 23 (4.9%) | ||||||
| T | 810 (71.7%) | 697 (74.6%) | ||||||
| C | 320 (28.3%) | 237 (25.4%) | ||||||
| rs762484 | 0.22 | 0.86 (0.69 to 1.09) | 0.36 | 0.89 (0.74 to 1.07) | 0.07 | 0.12 | ||
| TT | 374 (66%) | 330 (71%) | ||||||
| TC | 185 (32.6%) | 124 (26.7%) | ||||||
| CC | 8 (1.4%) | 11 (2.4%) | ||||||
| T | 933 (82.3%) | 784 (84.3%) | ||||||
| C | 201 (17.7%) | 146 (15.7%) | ||||||
| rs696619 | 0.31 | 0.91 (0.76 to 1.09) | 0.46 | 0.93 (0.79 to 1.06) | 0.14 | 0.26 | ||
| AA | 228 (40.7%) | 192 (41.5%) | ||||||
| AG | 271 (48.4%) | 237 (51.2%) | ||||||
| GG | 61 (10.9%) | 34 (7.3%) | ||||||
| A | 727 (64.9%) | 621 (67.1%) | ||||||
| G | 393 (35.1%) | 305 (32.9%) | ||||||
| rs3917615 | 0.87 | 0.98 (0.80 to 1.21) | 0.92 | 0.98 (0.83 to 1.18) | 0.07 | 0.16 | ||
| CC | 344 (61.3%) | 280 (59.5%) | ||||||
| CT | 189 (33.7%) | 179 (38%) | ||||||
| TT | 28 (5%) | 12 (2.5%) | ||||||
| C | 877 (78.2%) | 739 (78.5%) | ||||||
| T | 245 (21.8%) | 203 (21.5%) | ||||||
| rs1361600 | 0.53 | 0.94 (0.76 to 1.15) | 0.72 | 0.95 (0.82 to 1.12) | 0.07 | 0.16 | ||
| AA | 342 (60%) | 280 (59.6%) | ||||||
| AG | 198 (34.7%) | 178 (37.9%) | ||||||
| GG | 30 (5.3%) | 12 (2.6%) | ||||||
| A | 882 (77.4%) | 738 (78.5%) | ||||||
| G | 258 (22.6%) | 202 (21.5%) | ||||||
| rs958587 | 0.62 | 0.95 (0.77 to 1.17) | 0.78 | 0.96 (0.84 to 1.14) | 0.06 | 0.15 | ||
| CC | 342 (60.4%) | 279 (59.4%) | ||||||
| CT | 194 (34.3%) | 178 (38.0%) | ||||||
| TT | 30 (5.3%) | 12 (2.6%) | ||||||
| C | 878 (77.6%) | 736 (78.5%) | ||||||
| T | 254 (22.4%) | 202 (21.5%) | ||||||
| rs3917643 | 1.00 | 0.22 (0.25 to 6.05) | 0.85 | 0.29 (0.32 to 5.26) | 1.00 | 0.98 | ||
| AA | 570 (99.5%) | 468 (99.4%) | ||||||
| AG | 3 (0.5%) | 3 (0.6%) | ||||||
| A | 1143 (99.7%) | 939 (99.7%) | ||||||
| G | 3 (0.3%) | 3 (0.3%) | ||||||
| rs145977586 | 1.00 | 0.22 (0.25 to 6.05) | 0.85 | 0.29 (0.32 to 5.26) | 1.00 | 0.98 | ||
| GG | 570 (99.5%) | 468 (99.4%) | ||||||
| GA | 3 (0.5%) | 3 (0.6%) | ||||||
| G | 1143 (99.7%) | 939 (99.7%) | ||||||
| A | 3 (0.3%) | 3 (0.3%) | ||||||
| TFPI | ||||||||
| rs3755248 | 0.75 | 0.96 (0.75 to 1.23) | 0.67 | 0.87 (0.71 to 1.18) | 0.71 | 0.62 | ||
| TT | 412 (73%) | 342 (73.4%) | ||||||
| TC | 141 (25%) | 118 (25.3%) | ||||||
| CC | 11 (2%) | 6 (12.9%) | ||||||
| T | 965 (85.5%) | 802 (86.1%) | ||||||
| C | 163 (14.5%) | 130 (13.9%) | ||||||
| rs3213739 | 0.46 | 1.07 (0.90 to 1.28) | 0.32 | 1.15 (0.82 to 1.32) | 0.79 | 0.56 | ||
| GG | 270 (47.7%) | 218 (46.4%) | ||||||
| GT | 156 (27.6%) | 127 (27%) | ||||||
| TT | 140 (24.7%) | 125 (26.6%) | ||||||
| G | 696 (61.5%) | 563 (59.9%) | ||||||
| T | 436 (38.5%) | 377 (40.1%) | ||||||
| rs7594359 | 0.93 | 0.99 (0.78 to 1.25) | 0.94 | 0.94 (0.79 to 1.18) | 0.12 | 0.17 | ||
| CC | 389 (69.5%) | 317 (68.2%) | ||||||
| CT | 156 (27.9%) | 143 (30.8%) | ||||||
| TT | 15 (2.7%) | 5 (1.1%) | ||||||
| C | 934 (83.4%) | 777 (83.5%) | ||||||
| T | 186 (16.6%) | 153 (16.5%) | ||||||
| rs10931292 | 0.92 | 0.99 (0.82 to 1.19) | 0.82 | 0.78 (0.76 to 1.12) | 0.14 | 0.12 | ||
| TT | 255 (44.9%) | 222 (47.9%) | ||||||
| TC | 253 (44.5%) | 180 (38.9%) | ||||||
| CC | 60 (10.6%) | 61 (13.2%) | ||||||
| T | 763 (67.2%) | 624 (67.4%) | ||||||
| C | 373 (32.8%) | 302 (32.6%) | ||||||
| rs8176441 | 0.93 | 0.99 (0.81 to 1.21) | 0.82 | 0.76 (0.56 to 1.48) | 0.10 | 0.23 | ||
| TT | 300 (52.9%) | 259 (55.7%) | ||||||
| TC | 237 (41.8%) | 170 (36.6%) | ||||||
| CC | 30 (5.3%) | 36 (7.7%) | ||||||
| T | 837 (73.8%) | 688 (74%) | ||||||
| C | 297 (26.2%) | 242 (26%) | ||||||
| rs12613071 | 0.84 | 1.02 (0.84 to 1.23) | 0.75 | 1.24 (0.86 to 1.38) | 0.98 | 0.95 | ||
| TT | 288 (50.9%) | 233 (50.2%) | ||||||
| TC | 224 (39.6%) | 186 (40.1%) | ||||||
| CC | 54 (9.5%) | 45 (9.7%) | ||||||
| T | 800 (70.7%) | 652 (70.3%) | ||||||
| C | 332 (29.3%) | 276 (29.7%) | ||||||
| rs10153820 | 0.58 | 0.95 (0.79 to 1.14) | 0.62 | 0.98 (0.81 to 1.12) | 0.15 | 0.36 | ||
| GG | 254 (45.3%) | 230 (49.4%) | ||||||
| GA | 251 (44.7%) | 181 (38.8%) | ||||||
| AA | 56 (10%) | 55 (11.8%) | ||||||
| G | 759 (67.6%) | 641 (68.8%) | ||||||
| A | 363 (32.4%) | 291 (31.2%) | ||||||
| rs8176592 | 0.12 | 1.24 (0.94 to 1.63) | 0.36 | 1.16 (0.97 to 1.58) | 0.31 | 0.45 | ||
| TT | 461 (80.9%) | 363 (77.1%) | ||||||
| TC | 102 (17.9%) | 100 (21.2%) | ||||||
| CC | 7 (1.2%) | 8 (1.7%) | ||||||
| T | 1024 (89.8%) | 826 (87.7%) | ||||||
| C | 116 (10.2%) | 116 (12.3%) | ||||||
| rs2192824 | 0.79 | 1.03 (0.83 to 1.27) | 0.65 | 1.13 (0.92 to 1.46) | 0.76 | 0.68 | ||
| CC | 354 (62.7%) | 292 (62.7%) | ||||||
| CT | 185 (32.7%) | 148 (31.8%) | ||||||
| TT | 26 (4.6%) | 26 (5.6%) | ||||||
| C | 893 (79%) | 732 (78.5%) | ||||||
| T | 237 (21%) | 200 (21.5%) | ||||||
Data presented as number (%) of subjects. P was determined using the chi-square test. Padj and ORadj came from multivariate logistic regression. P <0.0029 (0.05/17) was considered statistically significant after Bonferroni correction. CI, confidence interval; OR, odds ratio; SNP, single nucleotide polymorphism; TF, tissue factor; TFPI, tissue factor pathway inhibitor.