Table 3.
Association analysis of SNPs in TF and TFPI between the survivor and nonsurvivor groups
| Gene | Survivor | Nonsurvivor | Allelic comparison | Genotypic comparison | ||||
|---|---|---|---|---|---|---|---|---|
| SNP | P 1 adj | OR 1 adj (95% CI) | P 2 adj | OR 2 adj (95% CI) | P 1 adj | P 2 adj | ||
| TF | ||||||||
| rs1324214 | 0.06 | 0.73 (0.53 to 1.01) | 0.12 | 0.78 (0.56 to 1.16) | 0.13 | 0.24 | ||
| CC | 165 (55%) | 103 (62.8%) | ||||||
| CT | 118 (39.3%) | 57 (34.8%) | ||||||
| TT | 17 (5.7%) | 4 (2.4%) | ||||||
| T | 448 (74.7%) | 263 (80.2%) | ||||||
| C | 152 (25.3%) | 65 (19.8%) | ||||||
| rs762484 | 0.13 | 0.75 (0.51 to 1.09) | 0.26 | 0.78 (0.82 to 1.07) | 0.32 | 0.38 | ||
| TT | 208 (68.6%) | 124 (74.7%) | ||||||
| TC | 85 (28%) | 39 (23.5%) | ||||||
| CC | 10 (3.3%) | 3 (1.8%) | ||||||
| T | 501 (82.7%) | 287 (86.4%) | ||||||
| C | 105 (17.3%) | 45 (13.6%) | ||||||
| rs696619 | 0.23 | 0.84 (0.63 to 1.12) | 0.38 | 0.86 (0.73 to 1.09) | 0.41 | 0.52 | ||
| AA | 122 (40.4%) | 75 (45.7%) | ||||||
| AG | 156 (51.7%) | 80 (48.8%) | ||||||
| GG | 24 (7.9%) | 9 (5.5%) | ||||||
| A | 400 (66.2%) | 230 (70.1%) | ||||||
| G | 204 (33.8%) | 98 (29.9%) | ||||||
| rs3917615 | 0.00015 | 0.50 (0.35 to 0.72) | 0.0018 | 0.69 (0.45 to 0.82) | 0.00014 | 0.0017 | ||
| CC | 167 (55.1%) | 123 (74.5%) | ||||||
| CT | 126 (41.6%) | 39 (23.6%) | ||||||
| TT | 10 (3.3%) | 3 (1.8%) | ||||||
| C | 460 (75.9%) | 285 (86.4%) | ||||||
| T | 146 (24.1%) | 445 (13.6%) | ||||||
| rs1361600 | 0.000049 | 0.48 (0.33 to 0.69) | 0.00045 | 0.57 (0.41 to 0.74) | 0.000024 | 0.00065 | ||
| AA | 164 (53.6%) | 124 (74.7%) | ||||||
| AG | 130 (42.5%) | 38 (22.9%) | ||||||
| GG | 12 (3.9%) | 4 (2.4%) | ||||||
| A | 458 (74.8%) | 286 (86.1%) | ||||||
| G | 154 (25.2%) | 46 (13.9%) | ||||||
| rs958587 | 0.0001 | 0.50 (0.34 to 0.71) | 0.0015 | 0.67 (0.43 to 0.79) | 0.000094 | 0.0016 | ||
| CC | 164 (53.9%) | 122 (73.9%) | ||||||
| CT | 130 (42.8%) | 40 (24.2%) | ||||||
| TT | 10 (3.3%) | 3 (1.8%) | ||||||
| C | 458 (75.3%) | 284 (86%) | ||||||
| T | 150 (24.7%) | 46 (14%) | ||||||
| rs3917643 | 0.62 | 1.84 (0.26 to 13.10) | 0.78 | 1.48 (0.76 to 14.07) | 0.62 | 0.78 | ||
| AA | 304 (99.3%) | 165 (98.8%) | ||||||
| AG | 2 (0.7%) | 2 (1.2%) | ||||||
| A | 610 (99.7%) | 332 (99.4%) | ||||||
| G | 2 (0.3%) | 2 (0.6%) | ||||||
| rs145977586 | 1.00 | 0.92 (0.08 to 10.14) | 0.95 | 0.93 (0.12 to 12.76) | 1.00 | 0.95 | ||
| GG | 304 (99.3%) | 166 (99.4%) | ||||||
| GA | 2 (0.7%) | 1 (0.6%) | ||||||
| G | 610 (99.7%) | 333 (99.7%) | ||||||
| A | 2 (0.3%) | 1 (0.3%) | ||||||
| TFPI | ||||||||
| rs3755248 | 0.75 | 0.94 (0.63 to 1.39) | 0.62 | 0.84 (0.56 to 1.23) | 0.13 | 0.11 | ||
| TT | 222 (72.8%) | 126 (76.4%) | ||||||
| TC | 80 (26.2%) | 34 (20.6%) | ||||||
| CC | 3 (1%) | 5 (3%) | ||||||
| T | 524 (85.9%) | 286 (86.7%) | ||||||
| C | 86 (14.1%) | 44 (13.3%) | ||||||
| rs3213739 | 0.16 | 0.82 (0.62 to 1.08) | 0.25 | 0.85 (0.72 to 1.04) | 0.44 | 0.52 | ||
| GG | 135 (44.7%) | 84 (50.9%) | ||||||
| GT | 84 (27.8%) | 41 (24.8%) | ||||||
| TT | 83 (27.5%) | 40 (24.2%) | ||||||
| G | 354 (58.6%) | 209 (63.3%) | ||||||
| T | 250 (41.4%) | 121 (36.7%) | ||||||
| rs7594359 | 0.18 | 0.78 (0.54 to 1.12) | 0.12 | 0.71 (0.46 to 1.09) | 0.23 | 0.18 | ||
| CC | 197 (64.8%) | 120 (71.9%) | ||||||
| CT | 104 (34.2%) | 45 (26.9%) | ||||||
| TT | 3 (1%) | 2 (1.2%) | ||||||
| C | 498 (81.9%) | 285 (85.3%) | ||||||
| T | 110 (18.1%) | 49 (14.7%) | ||||||
| rs10931292 | 0.44 | 0.89 (0.67 to 1.19) | 0.47 | 0.91 (0.81 to 1.13) | 0.38 | 0.49 | ||
| TT | 142 (47%) | 87 (52.7%) | ||||||
| TC | 122 (40.4%) | 56 (33.9%) | ||||||
| CC | 38 (12.6%) | 22 (13.3%) | ||||||
| T | 406 (67.2%) | 230 (69.7%) | ||||||
| C | 198 (32.8%) | 100 (30.3%) | ||||||
| rs8176441 | 0.87 | 1.03 (0.75 to 1.40) | 0.95 | 0.92 (0.61 to 1.32) | 0.06 | 0.17 | ||
| TT | 185 (60.9%) | 90 (55.6%) | ||||||
| TC | 89 (29.3%) | 63 (38.9%) | ||||||
| CC | 30 (9.8%) | 9 (5.5%) | ||||||
| T | 459 (75.5%) | 243 (75%) | ||||||
| C | 149 (24.5%) | 81 (25%) | ||||||
| rs12613071 | 0.91 | 1.02 (0.76 to 1.37) | 0.72 | 1.12 (0.83 to 1.58) | 0.32 | 0.21 | ||
| TT | 150 (50.2%) | 86 (52.8%) | ||||||
| TC | 124 (41.5%) | 58 (35.6%) | ||||||
| CC | 25 (8.4%) | 19 (11.7%) | ||||||
| T | 424 (70.9%) | 230 (70.6%) | ||||||
| C | 174 (29.1%) | 96 (29.4%) | ||||||
| rs10153820 | 0.20 | 1.21 (0.91 to 1.61) | 0.45 | 1.15 (0.82 to 1.46) | 0.25 | 0.52 | ||
| CC | 161 (53.5%) | 76 (45.8%) | ||||||
| CT | 105 (34.9%) | 70 (42.2%) | ||||||
| TT | 35 (11.6%) | 20 (12%) | ||||||
| C | 427 (70.9%) | 222 (66.9%) | ||||||
| T | 175 (29.1%) | 110 (33.1%) | ||||||
| rs8176592 | 0.35 | 0.81 (0.52 to 1.26) | 0.62 | 0.84 (0.71 to 1.19) | 0.34 | 0.58 | ||
| TT | 234 (77%) | 133 (81.6%) | ||||||
| TC | 68 (22.4%) | 28 (17.2%) | ||||||
| CC | 2 (0.6%) | 2 (1.2%) | ||||||
| T | 536 (88.2%) | 294 (90.2%) | ||||||
| C | 72 (11.8%) | 32 (9.8%) | ||||||
| rs2192824 | 0.48 | 0.89 (0.64 to 1.24) | 0.52 | 0.91 (0.72 to 1.19) | 0.38 | 0.41 | ||
| CC | 190 (62.9%) | 106 (63.9%) | ||||||
| CT | 94 (31.1%) | 55 (33.1%) | ||||||
| TT | 18 (6%) | 5 (3%) | ||||||
| C | 474 (78.5%) | 267 (80.4%) | ||||||
| T | 130 (21.5%) | 65 (19.6%) | ||||||
Data presented as number (%) of subjects. P was determined using the chi-square test. Padj and ORadj came from multivariate logistic regression. P <0.0029 (0.05/17) was considered statistically significant after Bonferroni correction. CI, confidence interval; OR, odds ratio; SNP, single nucleotide polymorphism; TF, tissue factor; TFPI, tissue factor pathway inhibitor.