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. 2014 Oct 11;14:84. doi: 10.1186/1472-6823-14-84

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© Appetecchia et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Histological and immunohistochemical examinations. A, B: Histology of primary medullary thyroid cancer; C: Metastasis of medullary thyroid carcinoma in the right inguinal lymph node; D: The right testis: histological examination shows trabecular solid areas with round and spindle cells of medullary thyroid carcinoma, partially separated by fibrous stroma infiltrating testicular parenchyma. Immunohistochemistry: Tumor cells show diffuse cytoplasmic positivity for TTF-1 (E) and with calcitonin (F).